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Inflammation stimulates the expression of PCSK9

✍ Scribed by Kenneth R. Feingold; Arthur H. Moser; Judy K. Shigenaga; Sophie M. Patzek; Carl Grunfeld

Book ID
116297124
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
374 KB
Volume
374
Category
Article
ISSN
0006-291X

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## Abstract Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key regulator of serum cholesterol. The possibility that PCSK9 also functions in other pathways needs to be addressed. We have transfected HepG2 cells with mutant D374Y‐PCSK9 or control vector. Gene expression signatures were de