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Inflammation-mediated chondrocyte unresponsiveness to insulin-like growth factor-1 is not caused by H2O2

✍ Scribed by L. A. B. Joosten; M. M. A. Helsen; W. B. van den Berg


Book ID
105416424
Publisher
SP Birkhäuser Verlag Basel
Year
1990
Tongue
English
Weight
176 KB
Volume
29
Category
Article
ISSN
1420-908X

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This study describes the mechanisms involved in the IGF-1 and IGF-2-induced increases in intracellular calcium concentration [Ca 21 ]i in cultured chondrocytes and the involvement of type 1 IGF receptors. It shows that IGF-1, IGF-2, and insulin increased the cytosolic free calcium concentration [Ca