## Abstract The past 25 years have seen a major expansion of knowledge concerning the cause of Parkinson's disease provided by an understanding of environmental and genetic factors that underlie the loss of nigral dopaminergic neurons. Based on the actions of toxins, postmortem investigations, and
Inflammation and Parkinson's disease pathogenesis
β Scribed by Serge Przedborski
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 49 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0885-3185
No coin nor oath required. For personal study only.
β¦ Synopsis
Abstract
Inflammation is a neuropathological feature of parkinsonian brains and also in experimental models of the disease. It is believed that activated glial cells, which compose the majority of this inflammatory response contribute to the neurodegenerative process through the production of toxic molecules. Therapeutic strategies geared toward reducing inflammation and inhibiting the production of these glialβderived toxic molecules may be a promising neuroprotective strategy for the treatment of Parkinson's disease and related conditions. Β© 2010 Movement Disorder Society
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