𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Inflammation and cancer: An ancient link with novel potentials

✍ Scribed by S. Perwez Hussain; Curtis C. Harris

Book ID
102272910
Publisher
John Wiley and Sons
Year
2007
Tongue
French
Weight
190 KB
Volume
121
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Infection and chronic inflammation contribute to about 1 in 4 of all cancer cases. Mediators of the inflammatory response, e.g., cytokines, free radicals, prostaglandins and growth factors, can induce genetic and epigenetic changes including point mutations in tumor suppressor genes, DNA methylation and post‐translational modifications, causing alterations in critical pathways responsible for maintaining the normal cellular homeostasis and leading to the development and progression of cancer. Recent discovery of an interaction between microRNAs and innate immunity during inflammation has further strengthened the association between inflammation and cancer. Β© 2007 Wiley‐Liss, Inc.

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