Inflammation and Atherosclerosis

✍ Scribed by F. Javier Nieto (auth.), Georg Wick, Cecilia Grundtman (eds.)

• Publisher: Springer-Verlag Wien
• Year: 2012
• Tongue: English
• Leaves: 627
• Edition: 1
• Category: Library

✦ Synopsis

It has been known for over 150 years that hallmarks of inflammation can be observed in the wall of atherosclerotic vessels. It was, however, not clear if this inflammation is the cause or the consequence of atherogenesis. More recently, it has become evident that inflammation mediated both by innate and adaptive immunity is instrumental even in the earliest stages of the development of atherosclerotic lesions, i.e., that it plays an important pathogenetic role. In this volume, international experts in the field discuss the pathogenetic, diagnostic, preventive and possible therapeutic relevance of inflammation in atherogenesis. This book is intended for researchers and physicians in the fields of vascular biology, immunology and atherosclerosis.

✦ Table of Contents

Front Matter....Pages i-ix
Historical Reflections on the Inflammatory Aspects of Atherosclerosis....Pages 1-17
Morphology of Atherosclerotic Lesions....Pages 19-37
Clinical Manifestations of Atherosclerosis....Pages 39-58
Intra-Aortic Hematopoietic Cells....Pages 59-75
The Vascular-Associated Lymphoid Tissue (VALT)....Pages 77-86
Vascular Endothelial Cells as Immunological Targets in Atheroscleroisis....Pages 87-114
The Role of Adhesion Molecules and Intimal Dendritic Cells in the Initiation of Atherosclerosis....Pages 115-131
Animal Models of Atherosclerosis....Pages 133-169
A Darwinian-Evolutionary Concept for Atherogenesis: The Role of Immunity to HSP60....Pages 171-196
Mediators of Vascular Inflammation....Pages 197-217
Pentraxins and Atherosclerosis....Pages 219-237
Interleukin-33 and Atherosclerosis....Pages 239-248
Proteomics of Atherosclerosis....Pages 249-266
Adipokines, Inflammation, and Atherosclerosis....Pages 267-288
Natural Antibodies and Atherosclerosis....Pages 289-304
NK/NKT Cells and Atherosclerosis....Pages 305-330
Macrophages and Atherosclerosis....Pages 331-352
Host Pattern Recognition Receptors (Toll-Like Receptors, RIG-I-Like Receptors, NOD-Like Receptors) and Atherosclerosis....Pages 353-383
Humoral Antibodies....Pages 385-396
Adaptive T Cell Immunity....Pages 397-421
Immunity to Low-Density Lipoprotein....Pages 423-434
Extracellular Matrix and Smooth Muscle Cells....Pages 435-460
The Role of Infection in Atherosclerosis and in Plaque Stability....Pages 461-480
Inflammatory Biomarkers....Pages 481-495
Atherosclerosis in Rheumatic Diseases....Pages 497-512
Anti-Inflammatory Therapeutic Approaches....Pages 513-528
Vaccination Against Atherosclerosis....Pages 529-553
Endocrinological Aspects of Atherosclerosis....Pages 555-581
Imaging of Atherosclerosis....Pages 583-611
Future Directions of Atherosclerosis Research and Translation into Clinical Application....Pages 613-623
Controversies and Open Questions....Pages 625-628
Back Matter....Pages 629-631

✦ Subjects

Immunology; Human Physiology; Endocrinology; Vaccine