Inflammation

✍ Scribed by S. E. Smith (auth.), Dr. John R. Vane, Dr. Sergio H. Ferreira (eds.)

• Publisher: Springer-Verlag Berlin Heidelberg
• Year: 1978
• Tongue: English
• Leaves: 808
• Series: Handbook of Experimental Pharmacology 50 / 1 : Inflammation
• Edition: 1
• Category: Library

✦ Synopsis

Throughout the centuries, inflammation has been considered as a disease in itself. This misconception arose from the inability to distinguish between inflammatory changes and the insults which induce them. The understanding of the distinction between the genesis of inflammation and the tissue reactions that follow is attributed to JOHN HUNTER, who, at the end of the 18th century, substantially contributed to the analysis of inflammation in objective terms. Today, however, we are still trying to find explanations for Celsus' Signs in terms of structural and functional changes occurring in the inflamed tissue. There are drugs which modulate these signs but, without a detailed knowledge of the basic physiopathological events, it is impossible to understand their mechanism of action. Notwithstanding, the effects of anti­ inflammatory drugs provided new knowledge of the relevance of the signs and symptoms to the sequence of biochemical and morphological changes occurring in inflammation. When we accepted the invitation to edit a Handbook on Inflammation and Anti­ Inflammatory Drugs, we were aware of the magnitude of the task. We knew the impossibility of covering the whole field in detail, especially taking into account the rapid accumulation of experimental knowledge which would, in all likelihood, overtake the process of publication.

✦ Table of Contents

Front Matter....Pages I-XXVII
Historical Survey of Definitions and Concepts of Inflammation....Pages 1-4
Front Matter....Pages 5-5
A Brief History of Inflammation....Pages 6-25
The Sequence of Early Events....Pages 26-67
Mononuclear Phagocytes in Inflammation....Pages 68-108
The Adhesion, Locomotion, and Chemotaxis of Leucocytes....Pages 109-137
Platelet Aggregation Mechanisms and Their Implications in Haemostasis and Inflammatory Disease....Pages 138-205
Regeneration and Repair....Pages 206-230
Immunological and Para-Immunological Aspects of Inflammation....Pages 231-266
The Release of Hydrolytic Enzymes From Phagocytic and Other Cells Participating in Acute and Chronic Inflammation....Pages 267-294
Lysosomal Enzymes....Pages 295-313
Lymphokines....Pages 314-342
Front Matter....Pages 343-343
Histamine, 5-Hydroxytryptamine, SRS-A: Discussion of Type I Hypersensitivity (Anaphylaxis)....Pages 345-373
Prostaglandins and Related Compounds....Pages 374-422
Front Matter....Pages 423-423
Complement....Pages 425-463
Bradykinin-System....Pages 464-522
Endogenous Modulators of the Inflammatory Response....Pages 523-567
Front Matter....Pages 569-569
Inflammatory Mediators and Vascular Events....Pages 571-587
Pain and Inflammatory Mediators....Pages 588-616
Prostaglandins and Body Temperature....Pages 617-656
Back Matter....Pages 657-786

✦ Subjects

Medicine/Public Health, general; Pharmacy