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Inflamed target tissue provides a specific niche for highly expanded T-cell clones in early human autoimmune disease

✍ Scribed by Klarenbeek, P. L.; de Hair, M. J. H.; Doorenspleet, M. E.; van Schaik, B. D. C.; Esveldt, R. E. E.; van de Sande, M. G. H.; Cantaert, T.; Gerlag, D. M.; Baeten, D.; van Kampen, A. H. C.; Baas, F.; Tak, P. P.; de Vries, N.

Book ID
121877779
Publisher
BMJ Publishing Group
Year
2012
Tongue
English
Weight
300 KB
Volume
71
Category
Article
ISSN
0003-4967

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## Abstract ## Objective To identify and characterize human T cells reactive with heterogeneous nuclear RNP A2 (hnRNP A2) antigen, and to determine the ability of hnRNP‐reactive T cells to assist in the production of human autoantibodies. ## Methods T cells from patients with high serum levels o