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Infiltrating macrophage count: A significant predictor for the progression and prognosis of oral squamous cell carcinomas in Taiwan

✍ Scribed by Chia-Fang Lu; Chiung-Shing Huang; Jeng-Wei Tjiu; Chun-Pin Chiang

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
380 KB
Volume
32
Category
Article
ISSN
1043-3074

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✦ Synopsis

Abstract

Background

Infiltrating macrophage count (IMC) is found to correlate with the progression and prognosis of many human cancers.

Methods

This study used immunohistochemistry to measure the IMC (macrophages/high‐power field [HPF]) in 92 specimens of oral squamous cell carcinoma (OSCC).

Results

A significantly increased IMC was found in OSCCs with larger tumor size, positive lymph node metastasis, more advanced clinical stages, or recurrence (all __p__s < .05). Kaplan‐Meier survival analysis found that OSCC patients with IMC >196 macrophages/HPF had a significantly shorter disease‐free (p = .001, log‐rank test) or overall survival (p < .001, log‐rank test) than OSCC patients with IMC <196 macrophages/HPF. Multivariate Cox regression analyses showed that IMC >196 macrophages/HPF was an independent predictor for poor disease‐free (p = .005) and overall survival of patients with OSCC (p = .015).

Conclusions

The IMC can predict the progression and prognosis of OSCCs in Taiwan. © 2009 Wiley Periodicals, Inc. Head Neck, 2010

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