Infiltrating lobular carcinoma of the breast: Clinicopathologic analysis of 975 cases with reference to data on conservative therapy and metastatic patterns
✍ Scribed by Xavier Sastre-Garau; Michel Jouve; Bernard Asselain; Anne Vincent-Salomon; Philippe Beuzeboc; Thierry Dorval; Jean-Claude Durand; Alain Fourquet; Pierre Pouillart
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 669 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0008-543X
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✦ Synopsis
BACKGROUND.
The clinicopathologic features of infiltrating lobular carcinoma (ILC), which represents 5% to 15% of all breast cancers, are still controversial. In particular, the high frequency of multicentric lesions has led to questioning of the effectiveness of conservative treatment for this type of cancer. By studying a large number of cases, we aimed to compare the clinicopathological features of ILC with those of nonlobular infiltrating carcinoma (NLIC) and to assess the advisability of conservative therapy in the management of ILC.
METHODS. The population analyzed included 726 cases of ILC, 249 cases of mired
ILCIinvasive ductal carcinoma (ILCIIDC), and 10,061 cases of NLIC. The age of patients, TNM status, estrogen-and progesterone-receptor status (ER, PH), and histologic grades of the 3 groups were compared. The follow-up was carried out on a subgroup of 5846 cases.