Inferences about the scale parameter of the gamma distribution based on data mixed from censoring and grouping
โ Scribed by Jie Mi; Arlene Naranjo
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 264 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0167-7152
No coin nor oath required. For personal study only.
โฆ Synopsis
This paper studies the MLE of the scale parameter of the gamma distribution based on data mixed from censoring and grouping when the shape parameter is known. The study shows that under Type I mixed data, the MLE of the scale parameter exists, is unique, and converges almost surely to the true value provided the number of items that fail in the last interval is less than the total number of items placed on test. Under Type II mixed data, these properties hold unconditionally. The relationship between the MLE's based on mixed data and censored data is also examined. An upper bound on the MLE under both Type I and II mixed data is derived to simplify the search for the MLE.
๐ SIMILAR VOLUMES
The steady-state and terminal volumes of distribution, as well as the mean residence time of drug in the body (V ss , V $ , and MRT) are the common pharmacokinetic parameters calculated using the drug plasma concentration-time profile C p (t) following intravenous (i.v. bolus or constant rate infusi