Infectious tolerance

✍ Scribed by Steve Cobbold; Herman Waldmann

• Book ID: 104358937
• Publisher: Elsevier Science
• Year: 1998
• Tongue: English
• Weight: 667 KB
• Volume: 10
• Category: Article
• ISSN: 0952-7915
• DOI: 10.1016/s0952-7915(98)80217-3

✦ Synopsis

Infectious tolerance can be induced in many ways, does not require a thymus or clonal deletion and can spread to thirdparty antigens linked on the same antigen-presenting cellthe process being variously described as linked-, bystanderor epitope-suppression. We here review the evidence concerning the mechanisms involved and attempt to make a consistent hypothesis, that during tolerance induction in the Thl-mediated autoimmune diseases and transplantation systems there would seem to be a phase of immune deviation towards Th2 cytokines, like IL-4 and IL-10; however, this may lead to an IL-10-induced form of anergy or nonresponsiveness and generation of the recently characterized Th3/T-regulatory-1 CD4 + T cell subset which is thought to downregulate the antigen-presenting cell, possibly via transforming growth factor 13.