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Infectious delivery and long-term persistence of transgene expression in the brain by a 135-kb iBAC-FXN genomic DNA expression vector

โœ Scribed by Gimenez-Cassina, A; Wade-Martins, R; Gomez-Sebastian, S; Corona, J-C; Lim, F; Diaz-Nido, J

Book ID
109855539
Publisher
Nature Publishing Group
Year
2011
Tongue
English
Weight
330 KB
Volume
18
Category
Article
ISSN
0969-7128

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## Abstract ## Background The delivery of a complete genomic DNA locus __in vivo__ may prove advantageous for complementation gene therapy, especially when physiological regulation of gene expression is desirable. Hydrodynamic tail vein injection has been shown to be a highly efficient means of no