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Infectious but non-leukemogenic friend leukemia virus obtained after prolonged cultivation in vitro

✍ Scribed by H. Yoshikura; Y. Hirokawa; Y. Ikawa; H. Sugano


Book ID
102274497
Publisher
John Wiley and Sons
Year
1969
Tongue
French
Weight
326 KB
Volume
4
Category
Article
ISSN
0020-7136

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✦ Synopsis


A non-leukemogmic strain of Friend leukemia virus ( F L V ) propagated in vitro interfered with infection by murine sarcoma virus (Moloney) ( M S V ) and acted as a helper of defective MSV. This suggests that the non-leukemogenic strain of FLV is infectious. After prolonged propagation in vitro, the Ieukemogenicity of a highly leukemogenic strain of FL V gradually decreased, while the infectivity assayed by iriterference with MS V infection remained unchanged.