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Infection with Leishmania infantum Inhibits Actinomycin D-Induced Apoptosis of Human Monocytic Cell Line U-937

✍ Scribed by SABRINA LISI; MARGHERITA SISTO; ANGELA ACQUAFREDDA; ROSA SPINELLI; MARIA ANGELA SCHIAVONE; VINCENZO MITOLO; OLGA BRANDONISIO; MARIA ANTONIETTA PANARO


Book ID
109253158
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
394 KB
Volume
52
Category
Article
ISSN
1066-5234

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Human monocytic leukemia U937 cells undergo apoptosis when treated with antitumor drugs, such as etoposide, camptothecin and mitomycin C. The molecular mechanism of the drug-induced apoptosis is not well understood. In this study, we found that 2-deoxyglucose (2DG), an analog of D-glucose and an ind