Infection of Thymidine Kinase-Deficient BHK Cells with Polyoma Virus
β Scribed by LITTLEFIELD, JOHN W.; BASILICO, CLAUDIO
- Book ID
- 109652343
- Publisher
- Nature Publishing Group
- Year
- 1966
- Tongue
- English
- Weight
- 327 KB
- Volume
- 211
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/211250a0
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π SIMILAR VOLUMES
A mouse cell line (LP1-1) was established from the murine L cells deficient in thymidine kinase (L-M(TK-] by prolonged selective culture on the hypoxanthine-aminopterine-thymidine (HAT) medium following transfection with the thymidine kinase gene of herpes simplex virus type-I (HSVTK). Southern blot
We have examined the effect of polyoma virus infection of primary mouse embryo cells on the tyrosyl kinase activity associated with the cellular src gene product, pp60c-src. The results of our studies demonstrate that infection of mouse cells with wild-type polyoma virus or viral mutants capable of