Infection-control guidelines for patients with the acquired immunodeficiency syndrome (AIDS): Conte JE, Hadley WK, Sande M, et al N Engl J Med 309:740–744 Sep 1983
✍ Scribed by Philip L Henneman
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- English
- Weight
- 189 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1097-6760
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✦ Synopsis
Forty children were selected for prophylaxis of recurrent febrile convulsions with either carbamazepine or phenobarbital sodium in a double-blind, controlled study. Criteria for entry were recurrent convulsions (two or more), complex convulsions, neurologic or developmental abnormalities, or one year or less of age at onset of febrile convulsions. Patients remained in the study until seizure free for 2 years, and serum drug levels were monitored during their course. Carbamazepine was found to be statistically less effective than phenobarbital. The 43% rate of recurrence with carbamazepine was approximately the same as the recurrence rate for untreated children in other studies. The authors conclude that carbamazepine is not as effective as phenobarbital in the prophylaxis of febrile convulsions.