Infarct size reduction by AT1-receptor blockade through a signal cascade of AT2-receptor activation, bradykinin and prostaglandins in pigs

Activation of ERK, JNK, Akt, and G-prote

Activation of ERK, JNK, Akt, and G-protein coupled signaling by hybrid angiotensin II AT1/bradykinin B2 receptors expressed in HEK-293 cells

✍ Jun Yu; David Lubinsky; Natia Tsomaia; Zhenhua Huang; Linda Taylor; Dale Mierke; 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 357 KB 👁 1 views

## Abstract Bradykinin (BK) and angiotensin II (AngII) often have opposite roles in cardiovascular diseases. Our aim here was to construct hybrid receptors which bind AngII but signal as BK. Various sequences of the intracellular face of the AngII type I receptor, AT1R, were replaced with correspon