The static design requirements of some seismic codes, such as the Eurocode 8 and-in most cases-the Uniform Building Code, to allow for the effects of earthquake excitation acting in a direction other than the principal axes of the structure do not apply to one-way asymmetric systems. Therefore, with some exceptions, no specific provisions are considered for such systems to cover effects of structural asymmetry on the behaviour of elements located along the symmetric system direction. Aimed towards fulfilling this need, in this paper, a wide parametric study of the inelastic response of one-way asymmetric systems designed according to Uniform Building Code is carried out, considering two-component earthquake excitations. The analyses show that the maximum ductility demands on elements aligned along the asymmetric system direction are very close to, and even lower than, those obtained for symmetric reference systems. Conversely, the symmetric direction elements undergo significantly larger inelasticity than if they were located in symmetric reference systems. Subsequently, the overstrength needed by the symmetric direction elements to prevent such additional ductility demands for several stiffness and plan configurations is quantified. It is concluded that one-way asymmetry should be considered by seismic codes as an intrinsic system property, thus implying that specific provisions should be included for designing elements located along the symmetric system direction, in addition to those currently subscribed to design the asymmetric direction elements.