✦ LIBER ✦

Ineffectiveness of inicarone, a fibrinolytic agent, alone or in combination with chemotherapeutic agents on spontaneously metastasizing murine tumours

✍ Scribed by Patrick Dumont; Ghanem Atassi; Robert Jager

Publisher: Springer
Year: 1983
Tongue: English
Weight: 502 KB
Volume: 1
Category: Article
ISSN: 0262-0898
DOI: 10.1007/bf00121197

No coin nor oath required. For personal study only.

✦ Synopsis

The effect of inicarone (L7035), a potent fibrinolytic, alone or in combination, was investigated on spontaneously metastasizing Lewis lung carcinoma (implanted intramuscularly) to verify whether it could prevent the formation of metastases. After intraperitoneal and oral administration, inicarone did not show any cytotoxicity since the survival of animals was not prolonged. Its activity was compared to that of warfarin, an anticoagulant: both drugs were inactive when administered in curative treatment and inicarone even enhanced the number of lung metastases. When administered in combination with cyclophosphamide, an antiproliferative agent, inicarone did not induce any synergism or antagonism, but this combination did not inhibit tumour growth or metastasis spreading. Moreover, when inicarone was combined with a potent antimetastatic agent, Nocodazole, it was shown to be in competition with the latter agent and totally overshadowed its activity; since inicarone had no antimetastatic effect, the number of metastases rose dramatically.

📜 SIMILAR VOLUMES

Effects of antiplatelet agents alone or

Effects of antiplatelet agents alone or in combinations on platelet aggregation and on liver metastases from a human pancreatic adenocarcinoma in the nude mouse

✍ George N. Tzanakakis; Kailash C. Agarwal; Dionysios K. Veronikis; Michael P. Vez 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 595 KB

There is ample evidence to suggest that hematogenous metastasis may be related to the ability of tumor cells to promote aggregation of host platelets. Arachidonic acid metabolism in platelets and vessel walls may also contribute to the metastatic process. Several preliminary trials of platelet inhib

CS-706, a novel cyclooxygenase-2 selecti

CS-706, a novel cyclooxygenase-2 selective inhibitor, prolonged the survival of tumor-bearing mice when treated alone or in combination with anti-tumor chemotherapeutic agents

✍ Michiyo Senzaki; Saori Ishida; Ayumi Yada; Masaharu Hanai; Kosaku Fujiwara; Shin 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 176 KB

## Abstract The potent chemopreventive activity of cyclooxygenase‐2 (COX‐2) inhibitors has been demonstrated in a number of preclinical studies, but their potency in antitumor activity is still in dispute. In this report, we demonstrate the potent antitumor activity of a novel COX‐2 inhibitor, CS‐7