Induction of α-Helix in the β-Sheet Protein Tumor Necrosis Factor-α: Thermal- and Trifluoroethanol-Induced Denaturation at Neutral pH
✍ Scribed by Narhi, Linda Owers; Philo, John S.; Li, Tiansheng; Zhang, Mei; Samal, Babru; Arakawa, Tsutomu
- Book ID
- 126984926
- Publisher
- American Chemical Society
- Year
- 1996
- Tongue
- English
- Weight
- 356 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0006-2960
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## Abstract The proinflammatory cytokine tumor necrosis factor (TNF) α is mainly produced in cells from the monocyte/macrophage lineage. TNFα is also a key signaling molecule in the liver functioning as an important physiological and pathogenic mediator. In hepatocytes or human hepatoma cells TNFα
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