Induction of tumour-specific immunity by manipulating the expression of major histocompatibility complex molecules on tumour cells
β Scribed by Kam M. Hui
- Book ID
- 109315147
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 422 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0378-1097
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## Peptide loading of empty major histocompatibility cornpiex molecules on RMA-S cells allows the induction of primary cytotoxic T lymphocyte responses" The antigcn processing-defectivc mutant cell linc RMA-S expresses at the cell surface major histocompatibility complex (MHC) class I molecules de
## Abstract Tumour necrosis factor alpha (TNF) mRNA is detected in the macrophage infiltrate surrounding the tumour, but the cellular/ molecular interactions leading to TNF gene expression in macrophages are unknown. The __in vitro__ system in which human blood monocytes are stimulated with human c
## Abstract The identification of endogenously produced antigenic peptides presented by MHC class I molecules has opened the way to peptideβbased strategies for CTL induction __in vivo__. Here we demonstrate that the induction __in vivo__ of CTL directed against naturally processed antigens can be