✦ LIBER ✦

Induction of tumor suppression and delayed-type footpad reaction by transfer of lymphocytes sensitized to a xenogenized tumor variant

✍ Scribed by R. Bianchi; L. Romani; P. Puccetti; M. C. Fioretti

Publisher: John Wiley and Sons
Year: 1988
Tongue: French
Weight: 570 KB
Volume: 42
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910420114

No coin nor oath required. For personal study only.

✦ Synopsis

Splenocytes immune to a highly immunogenic ("xenogenized", LS178Y/DTIC) variant of a murine lymphoma exert anti-parental-tumor activity in a systemic adoptive transfer system, the effect being apparently associated with the Lyt-2fraction of the lymphocyte population. During investigation of the mechanisms of this protection, we found that the LS178Y/DTIC tumor-immune lymphocytes exhibited an appreciable anti-15 178Y delayed-type hypersensitivity (DTH) response. Enrichment of those lymphocytes in L3T4' cells significantly enhanced the protective effect as well as the DTH reaction, whereas the use of an anti-L3T4 but not anti-Lyt-2 reagent blocked both activities. In vitro, lymphocyte proliferation against LS l78Y cells occurred and was apparently associated with the Lyt-2-fraction of a population of LS 178Y/DTIC immune splenocytes.

📜 SIMILAR VOLUMES

Inhibition of murine lymphoma growth by

Inhibition of murine lymphoma growth by adoptive transfer of lymphocytes sensitized to a xenogenized tumor variant

✍ R. Bianchi; L. Romani; P. Puccetti; M. C. Fioretti 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 French ⚖ 504 KB

Lymphocytes immune to a highly immunogenic ("xenogenized") variant of a murine lymphoma-which were shown to exert anti-xenogenized tumor activity in a previously described model of tumor immunotherapy-were tested in the present study for possible suppressive effects on the growth of an i.c. graft of