Induction of the in vitro p-hydroxylation of14C-amphetamine stereoisomers in phenobarbital-treated rats
โ Scribed by P. Medilanski; J. Corthay; A. Benakis
- Book ID
- 112658978
- Publisher
- Springer
- Year
- 1977
- Tongue
- English
- Weight
- 329 KB
- Volume
- 33
- Category
- Article
- ISSN
- 1420-682X
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๐ SIMILAR VOLUMES
The eects of age on hepatic microsomal enzyme induction were studied in male CD-1 mice. Six week old and 1 year old animals were treated with either phenobarbital (80 mg kg 71 ) or saline once daily for 3 d. Twenty-four hours after the last treatment, animals were sacriยฎced and livers were harvested
The localization of the form of cytochrome P-450 that is induced by phenobarbital was studied by direct immunofluorescence in the hepatocytes of rats pretreated with phenobarbital in comparison with saline-treated rats. Specific fluorescence was seen in the hepatocyte cytoplasm in saline-and phenoba