Chromosomal or allelic losses at 3p14 are common in a variety of human tumors, including those of the lung, breast, kidney, and head and neck. This suggests the existence of a tumor suppressor gene in this band. A promising candidate is the recently cloned FHIT gene, which spans the common fragile s
โฆ LIBER โฆ
Induction of the common fragile site FRA3B does not affect FHIT expression
โ Scribed by Michael, Dagmar; Rajewsky, Manfred F
- Book ID
- 110064536
- Publisher
- Nature Publishing Group
- Year
- 2001
- Tongue
- English
- Weight
- 181 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0950-9232
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Common chromosomal fragile sites are unstable genomic loci susceptible to breakage, rearrangement, and are highly recombinogenic. Frequent alterations at these loci in tumor cells led to the hypothesis that they may contribute to cancer development. The two most common chromosomal fragile sites FRA1