𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Induction of telomerase activity in stimulated human lymphocytes precedes expression of topoisomerase II α

✍ Scribed by H. Feist; R. Zeidler; T. Skrebsky; S. Schmatloch; H. Kreipe

Publisher
Springer
Year
1998
Tongue
English
Weight
278 KB
Volume
76
Category
Article
ISSN
0939-5555

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Ectopic expression of human topoisomeras
Ectopic expression of human topoisomerase IIα fragments and etoposide resistance in mammalian cells
✍ Angelika I. Ernst; Alex Soltermann; Jürg A. Sigrist; Lukas Widmer; Susan M. Gass 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 French ⚖ 596 KB

Cellular resistance to etoposide has been correlated both with reduced levels and an aberrant cytoplasmic accumulation of the drug's target, topoisomerase II␣ (topo II␣). It is not known, however, whether a cytoplasmic pool of topo II␣ is sufficient to confer drug resistance on cultured mammalian ce

Effect of extracellular magnesium on Top
Effect of extracellular magnesium on Topoisomerase II activity and expression in human leukemia HL-60 cells
✍ Valeria Covacci; Nicodemo Bruzzese; Alessandro Sgambato; Ram Ganapathi; Achille 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 200 KB 👁 2 views

Topoisomerase II (TopoII) is a Mg-dependent enzyme involved in topological modifications of DNA that are crucial to the regulation of cell proliferation and possibly differentiation. To investigate the role of Mg availability in the modulation of TopoII in whole cells, we studied enzyme activity and

Effects of wild-type p53 expression on t
Effects of wild-type p53 expression on the quantity and activity of topoisomerase IIα and β in various human cancer cell lines
✍ Daniel Hochhauser; Nikola I. Valkov; Jana L. Gump; Irene Wei; Carolyn O'Hare; Jo 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 455 KB 👁 1 views

The p53 null HL-60 cell line was transfected with plasmids coding for either the wild-type p53 or mutant p53 gene. The stable expression of wild-type p53 resulted in a significant increase in sensitivity to the topoisomerase II poisons etoposide and doxorubicin, but not to the topoisomerase II inhib

A lack of detectable modification of top
A lack of detectable modification of topoisomerase II activity in a series of human tumor cell lines expressing only low levels of etoposide resistance
✍ Bridget T. Hill; Richard D. H. Whelan; Louise K. Hosking; Sharon A. Shellard; Mi 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 471 KB

## Abstract Etoposide (VP‐16) resistance is expressed following __in vitro__ exposure of HN‐1 and MCF‐7 human tumor cells to the drug itself or to fractionated × irradiation. VP‐16‐selected sublines prove cross‐resistant to Adriamycin, amsacrine and actinomycin D, whilst X‐ray‐pretreated sublines s