✦ LIBER ✦
Induction of susceptibility to HgCl2 immune glomerulonephritis in the Lewis rat by immunocompetent cells from susceptible F1 hybrids
✍ Scribed by Catherine Sapin; Philippe Druet; Chantal Mandet
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- English
- Weight
- 395 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0014-2980
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✦ Synopsis
Abstract
Susceptibility to HgCl~2~‐induced glomerulonephritis was transferred to resistant Lewis (LEW) rats, irradiated and reconstituted with (LEW × BN)F~1~, hybrid immunocompetent cells. This glomerulonephritis was similar to that observed in Brown‐Norway (BN) rats with a first stage characterized by anti‐glomerular basement membrane antibodies and a second stage with immune complex‐type deposits in the glomerular tufts and in the small renal arteries.