Induction of sodium channel Nax (SCN7A) expression in rat and human hippocampus in temporal lobe epilepsy
β Scribed by Jan A. Gorter; Emanuele Zurolo; Anand Iyer; Kees Fluiter; Erwin A. Van Vliet; Johannes C. Baayen; Eleonora Aronica
- Book ID
- 109112803
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2010
- Tongue
- English
- Weight
- 896 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0013-9580
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## Abstract Degeneration of the CA3 pyramidal and dentate hilar neurons in the adult rat hippocampus after an intracerebroventricular kainic acid (KA) administration, a model of temporal lobe epilepsy, leads to permanent loss of the calcium binding protein calbindin in major fractions of dentate gr
The expression of brain-derived neurotrophic factor and the β£ subunit of calcium/ calmodulin-dependent protein kinase II mRNA in hippocampi obtained during surgical resections for intractable temporal lobe epilepsy were examined. Both calcium/calmodulindependent protein kinase II and brain-derived n