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Induction of protein growth factor systems in the ovaries of transgenic mice overexpressing human type 2 lysophosphatidic acid G protein-coupled receptor (LPA2)

✍ Scribed by Huang, Mei-Chuan; Lee, Hsin-Yu; Yeh, Che-Chung; Kong, Yvonne; Zaloudek, Charles J; Goetzl, Edward J

Book ID: 110068072
Publisher: Nature Publishing Group
Year: 2004
Tongue: English
Weight: 221 KB
Volume: 23
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1206986

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## Abstract Growth factor receptors of the tyrosine kinase family regulate proliferation of a variety of cell types. In some human cancers, the epidermal growth factor receptor (EGFR) and its ligands often are overexpressed, leading to both constitutive and autocrine activation. Intracellular signa