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Induction of protein catabolism and the ubiquitin-proteasome pathway by mild oxidative stress

✍ Scribed by Maria Cristina C. Gomes-Marcondes; Michael J. Tisdale

Book ID
117467275
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
227 KB
Volume
180
Category
Article
ISSN
0304-3835

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## Abstract The lysosomal apoptosis pathway is a potentially interesting therapeutic target. Since apoptosis involving the lysosomal pathway has been described to involve cathepsins, we screened a drug library for agents that induce cathepsin‐dependent apoptosis. Using pharmacological inhibitors an