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Induction of pinocytosis in cerebral vessels by acute hypertension and by hyperosmolar solutions

โœ Scribed by Dr. Hans-Arne Hansson; Barbro B. Johansson


Publisher
John Wiley and Sons
Year
1980
Tongue
English
Weight
883 KB
Volume
5
Category
Article
ISSN
0360-4012

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โœฆ Synopsis


Abstract

A new approach is described to study the mechanism of protein leakage through the endothelial cells in acute hypertension and after intracarotid infusion of hyperosmolar solutions. The luminal surface of the cerebrovascular endothelial cells was labeled with choleragenoidโ€peroxidase before the bloodโ€brain barrier (BBB) dysfunction was induced. Numerous pinocytotic vesicles and some transโ€endothelial channels were formed and showed labeling of parts of their membranes.

Our results indicate that the mechanism behind the protein leakage induced by hypertension and by hyperosmolar solutions is the same โ€“ ie, transendothelial pinocytosis.


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