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Induction of parallel human telomeric G-quadruplex structures by Sr2+

✍ Scribed by Ilene M. Pedroso; Luis F. Duarte; Giscard Yanez; Asmaa M. Baker; Terace M. Fletcher

Book ID: 116294898
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 469 KB
Volume: 358
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2007.04.126

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## Abstract Human telomeric DNA consists of tandem repeats of the sequence 5′‐d(TTAGGG)‐3′. Guanine‐rich DNA, such as that seen at telomeres, forms G‐quadruplex secondary structures. Alternative forms of G‐quadruplex structures can have differential effects on activities involved in telomere mainte