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Induction of p53 dependent apoptosis upon overexpression of a nuclear protein tyrosine phosphatase

โœ Scribed by Vegesna Radha; Ch Sudhakar; Ghanshyam Swarup


Book ID
117111027
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
308 KB
Volume
453
Category
Article
ISSN
0014-5793

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## Abstract Stress protein mortalin (mtHSP70) is highly expressed in cancer cells. It was shown to contribute to carcinogenesis by sequestrating the wild type p53, a key tumor suppressor protein, in the cytoplasm resulting in an abrogation of its transcriptional activation function. We have found t