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Induction of oxidative stress and DNA damage in rat brain by a folate/methyl-deficient diet

✍ Scribed by Tetyana V. Bagnyukova; Christine L. Powell; Oleksandra Pavliv; Volodymyr P. Tryndyak; Igor P. Pogribny


Book ID
113503717
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
543 KB
Volume
1237
Category
Article
ISSN
0006-8993

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## Abstract L‐2‐hydroxyglutaric acid (LGA) is the biochemical hallmark of L‐2‐hydroxyglutaric aciduria (L‐OHGA), an inherited neurometabolic disorder characterized by progressive neurodegeneration with cerebellar and pyramidal signs, mental deterioration, epilepsy, and subcortical leukoencephalopat