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Induction of ornithine decarboxylase by nerve growth factor dissociated from effects on survival and neurite outgrowth

✍ Scribed by GREENE, LLOYD A.; MCGUIRE, JEFFREY C.

Book ID: 109711240
Publisher: Nature Publishing Group
Year: 1978
Tongue: English
Weight: 558 KB
Volume: 276
Category: Article
ISSN: 0028-0836
DOI: 10.1038/276191a0

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## Abstract Nerve growth factor (NGF), epidermal growth factor (EGF), adenosine 3′,5′‐cyclic monophosphate (cAMP), and cholera toxin all increase the specific activity of ornithine decarboxylase (ODC) in the PC12 nerve‐like cell line. A phosphodiesterase inhibitor augments the effect of NGF on the