Induction of Murine Erythroleukemia Differentiation by Actinomycin D
β Scribed by Masaaki Terada, Elliot Epner, Uri Nudel, Jane Salmon, Eitan Fibach, Richard A. Rifkind and Paul A. Marks
- Book ID
- 123655184
- Publisher
- National Academy of Sciences
- Year
- 1978
- Tongue
- English
- Weight
- 714 KB
- Volume
- 75
- Category
- Article
- ISSN
- 0027-8424
- DOI
- 10.2307/68330
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π SIMILAR VOLUMES
Murine erythroleukemia cell lines derived from Friend virus infected mice can be induced to differentiate in vitro by numerous agents. Among these compounds are certain naturally occurring purines such as hypoxanthine or 1-methylhypoxanthine. We have extended these studies to other modified oxypurin
## Abstract Various Nβsubstituted polymethylene diamides were synthesized and tested for their potency to induce erythroid differentiation in murine erythroβleukemia cells. N,N,Nβ²,Nβ²βtetramethylβ1.6βhexaneβdicarboxamide (IIc) was the most potent inducer among 15 compounds tested. The effectiveness