Disruption of the murine mdr2 (multidrug-resistance) disease, characterized by a portal inflammation and a gene, which encodes a phosphatidylcholine flippase, ductular proliferation, is probably the consequence of leads to a hepatic disorder because of loss of biliary a toxic effect of bile acids on
Induction of multidrug resistance gene expression during cholestasis in rats and nonhuman primates
โ Scribed by Dieter Schrenk; Timothy W. Gant; Karl-Heinz Preisegger; Jeffrey A. Silverman; Pamela A. Marino; Snorri S. Thorgeirsson
- Book ID
- 118283756
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 954 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0270-9139
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P-Glycoprotein (PGP), a product of the multidrug resistance gene (mdr), acts as an adenosine triphosphate-dependent drug efflux system in cells. Initially, PGP was found in cancer cells, but it is now known that PGP is richly distributed in the adult brain. Passage to the central nervous system is l