Induction of mitochondrial permeability transition (MPT) pore opening and ROS formation as a mechanism for methamphetamine-induced mitochondrial toxicity

Sophoranone, extracted from a traditiona

Sophoranone, extracted from a traditional Chinese medicine Shan Dou Gen, induces apoptosis in human leukemia U937 cells via formation of reactive oxygen species and opening of mitochondrial permeability transition pores

✍ Sachiko Kajimoto; Noriko Takanashi; Tetsuya Kajimoto; Man Xu; Judong Cao; Yutaka 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 358 KB

## Abstract Screening of various natural products in a search for novel inducers of apoptosis in human leukemia cells led us to identify the strong apoptosis‐inducing activity in a fraction extracted with methanol from the roots of __Sophora subprostrata__ Chun et T. Chen. We purified the compound