Induction of mitochondrial permeability transition by auranofin, a Gold(I)-phosphine derivative

Direct evidence for rapid and selective

Direct evidence for rapid and selective induction of tumor neovascular permeability by tumor necrosis factor and a novel derivative, colloidal gold bound tumor necrosis factor

✍ Jeffrey M. Farma; Markus Puhlmann; Perry A. Soriano; Derrick Cox; Giulio F. Paci 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 869 KB

## Abstract Tumor necrosis factor (TNF) causes regression of advanced cancers when used in isolation perfusion with melphalan; evidence suggests these effects are mediated __via__ selective yet uncharacterized actions on tumor neovasculature. A novel derivative, colloidal gold bound TNF (cAu‐TNF) h