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Induction of mitochondrial oxidative stress in astrocytes by nitric oxide precedes disruption of energy metabolism

✍ Scribed by Jake Jacobson; Michael R. Duchen; John Hothersall; John B. Clark; Simon J. R. Heales

Book ID
111179127
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
392 KB
Volume
95
Category
Article
ISSN
0022-3042

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## Abstract There is an increasing body of evidence demonstrating that inhibition of cytochrome c oxidase by nitric oxide (NO) may be one more step in a signaling cascade involved in the physiologic regulation of cell functions. For example, in both astrocytes and neurons the inhibition of mitochon