Induction of metalloproteinase activity, cartilage matrix degradation and inhibition of endochondral mineralization in vitro byE. colilipopolysaccharide is mediated by interleukin 1α

Inhibition of interleukin-1α-induced car

Inhibition of interleukin-1α-induced cartilage oligomeric matrix protein degradation in bovine articular cartilage by matrix metalloproteinase inhibitors: Potential role for matrix metalloproteinases in the generation of cartilage oligomeric matrix protein fragments in arthritic synovial fluid

✍ Vishwas Ganu; Ronald Goldberg; Jane Peppard; John Rediske; Richard Melton; Shou- 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 918 KB

Objective. To determine whether matrix metalloproteinases (MMPs) degrade cartilage oligomeric matrix protein (COMP) to produce fragments similar to those found in synovial fluid (SF) from patients with arthritis. Methods. COMP fragments were generated in vitro by treating (a) bovine articular carti