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Induction of MDM2-P2 Transcripts Correlates with Stabilized Wild-Type p53 in Betel- and Tobacco-Related Human Oral Cancer

โœ Scribed by Ranju Ralhan; Agarwal Sandhya; Mathur Meera; Wasylyk Bohdan; Shukla K. Nootan


Book ID
117022278
Publisher
American Society for Investigative Pathology
Year
2000
Tongue
English
Weight
652 KB
Volume
157
Category
Article
ISSN
0002-9440

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A puzzling finding in various human tumors, including glioblastoma multiforme (GBM), is the stabilization of wildtype (wt) p53 protein. The biological significance of this phenomenon and the mechanism by which it occurs are unexplained. Recent reports have revealed that mdm2 exerts its negative regu