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Induction of matrix metalloproteinases (MMP3, MMP12 and MMP13) expression in the microglia by amyloid-β stimulation via the PI3K/Akt pathway

✍ Scribed by Sachiko Ito; Kenya Kimura; Masataka Haneda; Yoshiyuki Ishida; Makoto Sawada; Ken-ichi Isobe

Book ID: 113614944
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 309 KB
Volume: 42
Category: Article
ISSN: 0531-5565
DOI: 10.1016/j.exger.2006.11.012

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## Abstract As the primary immune effector cells in the CNS, microglia play a central role in regulating inflammation. The extracellular matrix (ECM) protein vitronectin is a strong inducer of microglial activation, switching microglia from a resting into an activated potentially destructive phenot