## Abstract Although administration of a single dose of __N__βnitrosoβ__N__ methylurea (NMU) to young virgin rats induces a high rate of mammary carcinomas, precise histogenesis of the carcinomas has not been well characterized. In this study, we investigated the alterations of Hβ__ras__ gene in ea
β¦ LIBER β¦
Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations
β Scribed by Sukumar, Saraswati; Notario, Vicente; Martin-Zanca, Dionisio; Barbacid, Mariano
- Book ID
- 109732992
- Publisher
- Nature Publishing Group
- Year
- 1983
- Tongue
- English
- Weight
- 633 KB
- Volume
- 306
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/306658a0
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## Abstract Humans are continually exposed to various environmental carcinogens. Cancers may arise as a result of exposure to carcinogenic chemicals, ionizing radiation or a combination thereof. However, the mechanism of combined carcinogenesis has been only deduced from oncogenic actions of indivi