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Induction of lacZ mutation by 7,12-dimethylbenz[a]anthracene in various tissues of transgenic mice

✍ Scribed by Noriyuki Hachiya; Nobuhiro Yajima; Shigeki Hatakeyama; Koichiro Yuno; Naoko Okada; Yuka Umeda; Akihiro Wakata; Yutaka Motohashi

Book ID
117767815
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
119 KB
Volume
444
Category
Article
ISSN
1383-5718

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## Abstract Transgenic mice carrying the bacterial __lacl__ gene in a lambda shuttle vector were used to isolate and characterize background and 7, 12‐dimethylbenz[__a__]anthracene(a) ‐induced mutations in skin. Adult male mice were treated once topically with either DMBA or acetone or were left un