To elucidate the pathophysiological mechanisms underlying chronic nerve-stretch injury, we gradually lengthened rat femurs by 15 mm at the rate of 0.5 mm/day (group L, n = 13). The control groups comprised sham-operated (group S, n = 10) and naive (group N, n = 8) rats. Immediately after the lengthe
โฆ LIBER โฆ
Induction of interleukin-6 in dorsal root ganglion neurons after gradual elongation of rat sciatic nerve
โ Scribed by Naoki Osamura; Kazuo Ikeda; Takaaki Ito; Haruhiro Higashida; Katsuro Tomita; Shigeru Yokoyama
- Book ID
- 116458535
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 658 KB
- Volume
- 195
- Category
- Article
- ISSN
- 0014-4886
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The present study deals with changes in numbers and sizes of primary afferent neurons (dorsal root ganglion [DRG] cells) after sciatic nerve transection. We find that this lesion in adult rats leads to death of some DRG cells by 8 weeks and 37% by 32 weeks after the lesion. The loss of cells appears