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Induction of insulin resistance in human skeletal muscle cells by downregulation of glycogen synthase protein expression

✍ Scribed by K.S. Park; T.P. Ciaraldi; L. Carter; S. Mudaliar; S.E. Nikoulina; N.J.G Webster; R.R. Henry

Book ID: 117828164
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 90 KB
Volume: 49
Category: Article
ISSN: 1532-8600
DOI: 10.1053/meta.2000.7717

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## Abstract We have used primary human muscle cell cultures to investigate the role of glycogen loading in cellular insulin resistance. Insulin pre‐treatment for 2 h markedly impaired insulin signaling, as assessed by protein kinase B (PKB) phosphorylation. In contrast, insulin‐dependent glycogen s