Induction of immune reaction against rat embryonal carcinoma by activation of viral genome

✍ Scribed by H. Sobis; L. Van Hove; H. Heremans; M. De Ley; A. Billiau; M. Vandeputte

• Publisher: John Wiley and Sons
• Year: 1980
• Tongue: French
• Weight: 668 KB
• Volume: 26
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910260115

✦ Synopsis

Abstract

A cell line (F3/I) derived from a rat embryonal carcinoma, originally induced in fetectomized rats injected with MSV, was found to be essentially non‐immunogenic in a syngeneic host; the cells did not produce C‐type virions. The MSV genome could be rescued by superinfection of F3/I cells with endogenous C‐type mouse virus and the cells were converted in a producer line‐F3/l‐P. The produced virus was shown to be MSV by its ability to induce focus formation in mouse fibroblasts. In contrast to its non‐producer ancestor, the F3/ I‐P line proved to be strongly immunogenic in the syngeneic host. These results indicate the possibility of converting certain non‐immunogenic tumors into immunogenic ones by the activation of dormant viral genome using xenogeneic non‐oncogenic helper virus.