Induction of IL-8 in periodontal ligament cells by H2O2
β Scribed by Yang-Sin Lee; Eun Jung Bak; Minyoung Kim; Wonse Park; Jeong Taeg Seo; Yun-Jung Yoo
- Book ID
- 107642962
- Publisher
- The Microbiological Society of Korea
- Year
- 2008
- Tongue
- English
- Weight
- 427 KB
- Volume
- 46
- Category
- Article
- ISSN
- 1225-8873
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π SIMILAR VOLUMES
Numerous studies have shown that hydrogen peroxide (H 2 O 2 ) inhibits proliferation and osteoblastic differentiation in bone-like cells. Human periodontal ligament fibroblasts (PLF) are capable of differentiating into osteoblasts and are exposed to oxidative stress during periodontal inflammation.
## Abstract Osteopontin is a protein found in the boneβrelated matrix and plays multiple regulatory roles in mineralizing and nonβmineralizing tissue. In osteogenic cellβlines, the expression of osteopontin increases with the progression of differentiation, but both the expression and function of o