Induction of HLA mutations by chemical mutagens in human lymphoid cells
โ Scribed by Donald Pious; Carl Soderland; Paul Gladstone
- Publisher
- Springer-Verlag
- Year
- 1977
- Tongue
- English
- Weight
- 22 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0093-7711
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๐ SIMILAR VOLUMES
Testicular cells of male mice were isolated, and the incorporation of tritium labeled thymidine into the DNA of the cells was estimated after exposure to various chemical mutagens. The normal semiconservative DNA synthesis was suppressed by the addition of hydroxyurea. Thirteen compounds were tested
That certain environmental chemicals can induce transmissible mutations in germ cells of experimental mammal is clear. The assumption that under certain conditions these chemicals are also likely to be mutagenic to human germ cells is not detectable. However, it is a difficult challenge to determine