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Induction of HIV-1 Nef-specific cytotoxic T lymphocytes by Nef-expressing DNA vaccine

✍ Scribed by Asakura, Yusuke; Hamajima, Kenji; Fukushima, Jun; Mohri, Hiroshi; Okubo, Takao; Okuda, Kenji

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
167 KB
Volume
53
Category
Article
ISSN
0361-8609

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✦ Synopsis

Recently, some individuals who have remained seronegative despite definite exposure to HIV-1 have been reported. Among these individuals, an unusually high frequency of HIV-1 Nef-specific cytotoxic T lymphocytes was observed. Direct injection of plasmid DNA encoding foreign antigen can elicit both cell-mediated immunity and antibody responses (DNA vaccine). We constructed an HIV-1 Nef-expressing plasmid, and we induced HIV-1 Nef-specific cytotoxic T lymphocytes. This is the first report of inducing HIV-1 Nefspecific cytotoxic T lymphocytes by DNA vaccine.

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✍ Dorine Chassin; Muriel Andrieu; William Cohen; BΓ©atrice Culmann-Penciolelli; Mar πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 132 KB πŸ‘ 2 views

The HIV-1 Nef protein down-modulates surface expression of MHC class I proteins. Primary infected T lymphocytes thus escape lysis by cytotoxic T lymphocytes (CTL). In contrast, during HIV-1 infection there are strong CTL responses to several HIV proteins, and there is mounting evidence that CTL are